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It means really drunk and high or any form of being really messed up. used alot in Florida.
Dang homie last night I was slayed.
slayed by Bezzled August 16, 2007
adj. Offensively Ugly, unattractive.
"The bitch was slayed."
Slayed by Dom-inator October 20, 2005
To kill or un-liveth.
"I absolutely slayed that thot."
Slayed by toowiligo May 6, 2020
"I absolutely slayed that thot."
Slayed by toowiligo May 6, 2020
When you get dissed, told off, or when someone notifies you of the fact that your joke sucks ass. Also when you try to slay someone and someone notifies others around you that your joke sucks and leaves you clueless. OR when your joke sucks and someone around you notifies others that it sucks.
hillary "your so fat you eat babies"
johnny "what the hell kinda joke.."
everyone around her "slayed"
Slayed by adam monroe December 18, 2005
Derrived from slain, sometimes written 'slaid'.

Off the cuff real-life synonym of 'owned' or 'pwned'. Can be derogatory or supportive...
Mike: My girlfriend just dumped me.
Ellie: Oh, slayed!

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Nic: Oh man, Josh got totally slayed by that girl, she kicked him in the nuts!
slayed by Mike May 13, 2005