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Modeled after the term used in Biology, where genus of Protozoa consists of unicellular organisms that do not have a definite shape

"Amoeba" is generally used for one of two things, outside of biology;

1. A word used after another person does something respectable

2. A word used after another person does something to make you not want to live on the same planet as them
Friend 1: Hey, I just had a one night stand with Derpette last night!

Friend 2: Amoeba

or

Friend 1: I Just pissed myself.

Friend 2: Amoeba.
Amoeba by fushave October 8, 2013
a shape of a pool. refered to in the movie Lords of dogtown to empty pools.
Red Dog: Hey man check out the amoeba next door
amoeba by ya man March 12, 2007
A dance invented by Rob Hebrank. To do it one must pretend he is a spineless sea animal and wiggle like like they have never wiggled before. Oh ya Rob has a large penis and does the helicopter frequently.
Rob busted out the amoeba at this party and got laid by like 20 filipino chicks at once.
amoeba by Twin Betty February 23, 2005
A song by a grunge/metal band The Adolescents. It's known for being on Grand Theft Auto V and for being extremely awesome.
Science teacher: Victor, tell me what an Amoeba is.
Victor: It's a song that is fucking amazing.
Science teacher: You're wrong, but you're also right.
Amoeba by Retard_Ryan November 1, 2022
a group of really close friends or a tight-knit group of friends
the most popular clique in the school was the amoeba
amoeba by xoxlovexisxpainxox April 30, 2005
Brazillian slime toy. Sticky, smelly, and absolutely marvelous. You can make many things with it, like bubbles, big bubbles and stains on the wall.
"Let's go play with Amoeba!"
Amoeba by Lorob44 December 7, 2016