To literally go insane, usually accompanied by flailingarms, incomprehensible gurgling noises and a crazed look.
Did you see that guy going down the residential area at 110 mph? He went through someones fucking lawn, THEIR GODDAMN LAWN AND THROUGH THE FENCE TOO. God, then he got to the orphanage, it was a massacre. I tell ya man, he was going ape shit.