(adj.) being in a state in which one is utterly and completely unable to distinguish fact from fiction, and is thus obviously and undeniably full of shit.
Most politicians are reality challenged. So are a number of attorneys, as well as most people living in Hollywood.
To use it in a sentence: "That guy is SO reality challenged... that he can't even tell shit from Shinola!"
The Demons of Doom Eternal are referred to as "Mortally Challenged". Its a silly joke in the game. A few Liberals are upset about this and they claim that the game equates Demons with Immigrants. Which is not true.
Blue Hologram Chick : Remember, "Demon" can be an offensive term, refer to them as Mortally Challenged