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short a couple chromosomes

idiom/adjective phrase: to be mentally deficient in a very noticeable manner.

Etymology:

From the fact that many cases of mental retardation involves having an abnormal number of chromosomes.

Notes:
Funnily enough, means the same thing as "to have a couple extra chromosomes". "To be short a couple chromosomes" is perhaps a more natural way of expressing the idea as it plays to the human intuition that "more is better" and also because it is very easy to imagine how someone without the normal number of chromosomes could turn out retarded; however, "to have a couple extra chromosomes" may actually be more accurate in most cases. The most common genetic cause for mental retardation is Down's syndrome, which actually involves having more chromosomes than the normal person (a third copy of chromosome 21, to be precise).
I asked Zoe why her cousin was such a manchild, and she said, "Oh, he's short a couple chromosomes."
by Choosy Floozy November 24, 2019
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Seminal Short Cake

When a short, robust woman is cream pied
Dude! Last night I turned my girl into a seminal short cake.
by Blossom_Shinagains September 21, 2019
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Eat My Shorts

Bart simpson's PG way of saying "Eat My Ass"
"eat my shorts!"
by AugustTheHornyInventor July 24, 2022
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Short bus deligaton

Group of people when they get together, act so foolishly that you think they rode the short bus together.
Look at these guys from hooters. They obviously think the girls are hot. To bad they’re apart of the Short bus deligaton
by Colin33448 November 22, 2017
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Big Boy Shorts

A piece of clothing often worn by kids who beat up infants with boxing gloves in the playground. It is a sign of raw strength and power to all preteens or tweens.
Jerry McFuckface: Hey, here comes Walter with his Big Boy Shorts!
Gary Pussington: Shit, we better skrrt, homie!
by BadNightmarez November 8, 2018
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Mr Short Cummings

This refers to men who either has a small penis, doesn't last long during sex or has very poor performance in the bedroom. Women will often shame men like this with no regards for their feelings.
Being called Mr short Cummings can break down a man's confidence, pride, ego & self esteem.
Tasha: this guy was so dead & boring in the bedroom I was on my phone most of the time.

Layla: loool Mr short Cummings.. lock that off sis
by Arron j smith April 7, 2022
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