Duff

A blonde chicks vagina.

"Hillary's duff"
"Go get you some of that duff over there"
"I bet that chick has a nice duff"

by Fagboyslim88 January 13, 2017

duff bag

A monster tard you work with. Usually nothing good comes out of there mouth. Comparable to douchebag

Duff bag just moves around the office soundung drunk

by Going6to6hell6 January 19, 2017

duffed

too be high as fuck

me and angel was so duffed last night we left the car on the whole night

by mhndzxo February 12, 2017

Duff

dumb ugly or fat friend...

Becky invited her duff so she doesnt get wasted and blows any willing cock within sucking distance

by NorCal Slanger March 27, 2017

DUFF

Abv. For Designated Ugly Fat Friend. Usually the one person more approachable in a group and the one who is less attractive than all the others in the group. Sometimes a girl will approach a DUFF and start to flirt but after a while will begin to ask questions about another hotter member of the group.

Man #1: Dude, that's your job as the DUFF
Man#2: What did you just say to me?
Man#1: You're a DUFF, Designated Ugly Fat Friend.
Man#2: That's so messed up.

by Sugary sweet April 7, 2017

Duffelfuck

A woman who's vagina is big and loose like a duffel bag.

Man, I was with Mary last night and she is a duffelfuck.

by Ambojet April 11, 2017

duffus fuck

a duffus fuck is a fella who is a complete dumb shit in life and don't know how to react to being called duffus fuck

hey Patrick you are a duffus fuck

by duffusfuck April 14, 2017