A philosophical statement written on Mamimi's cigarette in the show, Fooly Cooly (FLCL). Some viewers believe that the full message is in fact, "Tasuku Never Knows Best," but it is disputed. The significance of the quote is relative to the individual.
A response to all the stuff from Japan westerners think of as "weird" (Tentacle porn, Japanese game shows, etc.) It blames the cultural differences between western countries and Japan as an effect of the radiation from the two nukes dropped on Japan under World War 2.
"Where does hentai come from?"
"I don't know, but it's probably from Japan ."
"I guess that's why you should never nuke a country twice."