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When the question/response is "what" but not just "what", implying that the speaker is responding in an irritated or frustrated or confused way, and that an additional "...is the problem" or "...is your issue" or "...the hell is going on" comes right after but is unsaid.

If the person wants, they can say the unsaid, for emphasis.
Examples:

Girl: (for the 10th time) "Um can you seriously come over here and look at this?"

FriendofGirl: (busy doing something else) "Whaz?!?!! What IS it? What is the deal with you, biznitch?!!"

or

NewsReporter: "...coming down the I-95 at 87 miles an hour, then flipping over and bursting into flame near the exit to Main street!"

Person watching TV: (disbelief) "Whaaz...? I was just over there 5 minutes ago!!"

or

Mother: "Joey, will you GET over here right now?"

Joey: (playing down the street) "Maaaa, whaaaaazzz???"

or

Dude #1: (large black thing flying by at high speed) Dude, wtf?? Wtf was that?!?!

Dude #2: (looking confused/stoned/out of it) Huh, wha? Whaz goin on??
whaz by Vallara October 17, 2009
Related Words
whazz Whaz whazup whazzle whazzup whazik whazoo whazza Whazz Gutta? whazzuuup
Doesn't really mean anything. Can be used in millions of places.
You're pretty whaz.

This tastes whaz.

whaz up? 

Often said by an stoned or drunk motherfucker walking into a party of stoned and drunk motherfuckers.
Stoned guy: Whaz up? Everybody in the room: Whaz up?
whaz up? by JoeyBomm June 15, 2020

Whizz-Whazz Pickle Spazz 

A fancy word for Penis. Your crush is 85% likelier to fall in love with you if you use this word on them. Just hearing this word sends shivers down a person's spine. This word is so effective because it stresses on the "whizz" part, causing your future partner to visualize your penis and just fantasize.
Why use "penis" when you can use this word instead?
"Hey, wanna see my Whizz-Whazz Pickle Spazz?"
"Of course! And while you're at it, why not consider marrying me?"
"I need to take a Whazz"
whazz by REDEMON September 18, 2018
Short for "What's up".

Used in chat rooms, messengers, etc
ChatMan: Hello.
ChatPunk: Whazzup, man.
whazzup by Gabriel May 13, 2005