John Stamos 

1. An actor who portrayed Uncle Jesse on Full House from 1987-1995, he originally became famous from starring in a soap opera called general hospital, and was on a show recently called ER, and has also done some Broadway shows in the early 2000's.

2. The sexiest man alive, great personality and a sultry voice.

"Oh my god who is that hot guy on full house?"
"Oh that's uncle Jesse aka John stamos aka the sexiest man alive"

John Stamos by Madison P April 29, 2015

John Stamos 

it is quite possible that john stamos is the coolest individual to walk the earth. he has it all, from sweet hair to good looks to tight pants. definitely the best character from full house, aka uncle jesse. the "epitomy of coolness", john stamos is the guy every girl wants to date. every guy wants him as their best friend. he knows whats hip, cool, and he teaches DJ, stephanie, and michelle every moral they've ever learned.

john stamos` ex-wifes name is rebecca. my name is rebecca. coincidence? i think not. marry me, john stamos.

john stamos is the hottest guy ever, next to brad pitt.

jeez, look at that guy`s hair. he looks exactly like john stamos. sweet.

John Stamos by john stamos` lover. rebecca. September 5, 2008

John Stamos 

1. Uncle Jessie from Full House
2. Taking a poop, while masterbating, and eating a bowl of cereal. A variation of the Bob Saget.

I did a John Stamos after watching full house.

John Stamos by L. Roman July 16, 2006

John Stamos 

A Vodka shot lit on fire for a good 3 seconds before dumping it in YooHoo (chocolate milk) and chugging it.

Margaritas are sour, and John Stamos are sweet.

John Stamos by muffinmonk May 30, 2011

John stamos 

An action

I just john stamosed him.

John stamos by Yodela September 23, 2017

John Stamos 

He is the hottest American actor in the world. He slayed In she show full house as his character “uncle Jesse” he is fucking incredible and anyone who says he isn’t doesn’t have a fucking brain

John Stamos is fucking hot

John Stamos by Fullhousesuperfan January 23, 2019

John Stamos 

A beverage that consists of Mountain Dew and Lemonade.

Person 1 : "Hey man what are you drinking?"
Person 2: "I'm just having a John stamos"

John Stamos by Tang tickler cockblast July 25, 2017