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McFail is used to describe failure on a large scale. It is used when the word fail or failure just won't cut it.
"Sean McFailed at nearly everything he did."

"I can't believe you did that, you're such a McFail!"
McFail by Barney1983 May 6, 2009
When Mickey D's fucks up on your order
Quint goes to the local McDonald's and orders a huge Big Mac. He goes to his table, and as soon as he gets his food, he realizes that they gave him a Happy Meal cheeseburger instead.

"Goddamnit, another McFail!" he yelled as he yeeted his tray across the room.
McFail by RedRabbit1987 March 5, 2019
when u go large with something at mcdonalds and realise u can't eat all of it therefore looking like a twat
person1: im goin large
10 minutes later.....
person2: why did u go large??
person1: i shudn't have im full
person2: ur not gona eat that half portion of chips left
person1: no
person2: haha mcfail!!!

McFail meal 

McFail meal $1.49
when your eating out a skeletor and u get this werid taste in your mouth and there is a werid smell, and then one random day u smell your B.O. and its the same thing as when u were eating out skeletor causeing u to fall to the ground in shambles and quiver in fear for hours for you have realized what you have done and u r now morbidly descusted forever.
the mcfail meal was the worst $1.49 ever spent and has killed my sex drive
McFail meal by pat. john November 19, 2007

john mcfail 

The losing candidate of the 2008 election. Originally named John McCain until his concession speech in which he says "the failure is mine, not yours" He pretty much sets himself up for this one.
john mcfail by McFailure March 19, 2009

Fergus McFail 

Statement made when referencing Fergus McPhail, optimistic main character of the Australian children's comedy series that was released on Network Ten in 2004, of the same name.
Kid asks a girl out, gets rejected
Kid's friend: 'Oooh, duuuude, Fergus McFAIL!!!'