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To spend an entire night together and not miss a single high-five.

Comes from the idea that people spending time together will have fun and give each other high fives. Since the geek culture boom in the 80's, it's become much easier for a high-five to miss. If one avoids this tragic accident of pop culture, one has been said to be "five-up."
There was a minute there when I thought Brad was going to miss my hand, but he made it, so we were five-up.
five-up by Cap'n Awesome May 2, 2005
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To meet with a group of people; hangout.

Comes from carpooling where you get in groups of five to save gas.
We have to drive pretty far, so let's five-up at my place to save gas.

Hey, you wanna five-up at the mall to go shopping?

Let's five-up at my place to watch a movie.
five-up by heads up five up April 24, 2011
The same gesture as the famous High five but a more friendly term that can be exclaimed without making one look/sound like a high-fiving douche bag.
"So these frat boys in their Lexus' tried racing me in my VW, and I totally let them blow past just to watch the cops pull them over... Up Five!"

in lieu of an after-sex high five: "YEAH! I just banged the shit out of you! Up Five!"
Up Five by Dan Ray May 23, 2008

Five fingers up 

If you see a person popping fives they mostly likely gay or get no money
Don’t pop 5s big 4s five fingers up are for pussys

Drop a bomb from five foot up 

In act in which one stands upon the toilet seat and proceeds to release a giant turd into the toilet. Amateurs make a large splash. Professionals make no splash. For some, this is better than sex.
"Dude! last night I want to drop a bomb from five foot up and it made no splash, but Granny was over."

five ngihts up my ass

when youre up my ass for five nights
hjjfdknj : " fnuma "
gfwsdeth : " tf "
hjjfdknj : " five ngihts up my ass "
five ngihts up my ass by bhsjdmbkxcvh September 30, 2021

five fingers up 

that means you pull only men...
John has five fingers up,
he must only pull men.
five fingers up by gayemokid September 11, 2022