Ham off Share definition Flag When two individuals go hard as a motherfucker against eachother in a face off of true drunken/drugged skill. Yo, Dalton, HAM OFF THIS WEEKEND BRO? TOTALLY man, you won't even be able to handle it. Ham off by stare November 6, 2011 0 0 Get merch Get the Ham off mug. Buy Now — $32.95 See more merch