sis 

NOT to be associated with james charles, but as a universal answer to questions. originated in stan twitter. also refers to any random person, whether you know them or not.

person 1: sis, look at her pants!
person 2: dang, sis lookin sharp!!
person 1: do u think i should ask her where they’re from??
person 2: sis-

sis by yeehawwwwwwwwwww May 11, 2019

SIS 

Commonly used by fake friends to throw you off of there true intentions towards you , Usually said before they ask you for something

Hey SIS what u doing today? "I'm bout to go to the bank then get my nails done" Ohh I'm broke as hell .U got me till next week ?

SIS by DAPPER DAN84 September 12, 2019

sis 

What you use when talking to someone

Charlie: hi how are you
Abby: yesterday was terrible
Charlie: sis spill what happened

sis by bitch who the fuck is you August 19, 2020

Sis 

noun
1.
referencing an individual (not gender specific) who is aligned with the ideology of intersectional feminism, gender parity and the humanist approach to gender rights - an anti-exclusionary and future-focused/future-minded approach to combat the current exclusion issues in the zeitgeist for gender rights.

2.
term of endearment to signal solidarity with and/or feelings of attachment toward the individual to whom the speaker is referring.

"Hey Sis, how are you?"

"you just like my Sis ..ill send you her insta so you can follow."

Sis by woahnellie September 10, 2020

Sis 

Used to be sassy, sarcastic, SIS.
Sis is just such a cute word!!!

Sis-

Sis- NO
Sis that's so cute!

Sis by t_xo88 September 27, 2020

Sis 

Ur BEST girly friend in the whole frickin world!!!!!

Hey sis!

Sis by Noney the pony May 21, 2021

Sis 

girl mentally ill who doesn't know what's going on

falls in love at people who are terrible don't respect her and hate her
everyone who was friends with her hates her and wishes her death
she loves herself

loves to talk about her feelings
her astro birth chart say she is awful person

Sis you can't fall in love with him, he's an imitation of a man, he's not even a half man

Sis by Borntodiesis July 8, 2021