Top definition
Short for the word “sister” but also just an answer to any question ever.
Susan: “how was your weekend?”
Janet: “sis...”
Susan: “omg sis what’s the tea sis—spill!”
Janet: “sis!”
Susan “sis”
—and so on and so forth until Antichrist comes and the world is over
by Theworldisflat.edu August 03, 2018
Get the merch
Get the Sis neck gaiter and mug.
Sep 6 Word of the Day
Style with Ease
Damn that was a steezy ass kickflip son!
by niggaliciouszor April 29, 2007
Get the mug
Get a steezy mug for your guy Callisto.
2
Short for sister, commonly used as a term of endearment to friends in urban new york/jersey areas
by Caroline Might Fine November 14, 2016
Get the mug
Get a sis mug for your friend José.
3
Not meaning “sister”. Commonly used to refer to a close friend or bestfriend.
what’s up, sis”
by kaitlyn pender January 24, 2019
Get the mug
Get a sis mug for your Aunt Jovana.
5
1) Short for sister
2) In the song Fuck the Pain Away by Peaches, SIS seems to stand for Stay In School...
My sis went to the movies with a scumball.

"Stay in school... Cause it's the best..."
by wxynot July 12, 2005
Get the merch
Get the sis neck gaiter and mug.
6
Abbreviation for: "Sisters, In, Spirit". Your Best Friend or Bae. Usually used to refer to someone really close to you, someone you spend a lot of time with, like your sister.
Girl: OMG, squad on fleek!
Girl 2: yas, we look #Fabulous
Girl: Yas Sis Yas!
by ChocolateWafflez April 15, 2015
Get the mug
Get a SIS mug for your dog Abdul.

Activity