Short for the word “sister” but also just an answer to any question ever.
Susan: “how was your weekend?”
Janet: “sis...”
Susan: “omg sis what’s the tea sis—spill!”
Janet: “sis!”
Susan “sis”
—and so on and so forth until Antichrist comes and the world is over
by August 3, 2018
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1. A term used as a confidence booster by black females in order to 'hype' their self-esteem.

2. A phrase used frequently by close female friends who share a special bond from others.

3. A term used by a female to reassure another female that she will always be there to defend, honour and keep her from committing bad decisions.
Kidist, you mah sis and always will be. Happy Birthday boo 💛
by kidoblack February 19, 2018
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A word basic bitches use to get a point across.
It’s the most cringe worthy word that can be used and should be illegal in every way.
“Omg sis I just got a brand new Rolex
Sis hop in my fiat500 let’s go for a ride”
by Shanosthetranos July 7, 2020
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A sexual nickname used by gang members
by Gang guy 254 January 29, 2016
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A perfect response to your friend saying something stupid, bitchy, slutty or just something u can't think of a reply to
Person 1: Idk which guy to meet this weekend, there's a choice of 3
Person 2: sis
by Theteakeeper January 12, 2019
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