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Second Life 

A game where desperate people with no lives or friends get to live out their dreams of social acceptance and sex.
The vast majority of Second Life players are unattractive and socially awkward.
With Second Life, nerds everywhere that are deprived of sex in their 1st life can have virtual sex in their Second Life. Woo!
Second Life by Kaptain Kangeroo April 30, 2009

second lead syndrome 

Second Lead Syndrome is the closet thing to death that isn't. Second Lead Syndrome is when you are casually watching your Kdrama and you starts to ship the female lead with the second male lead. Or when you start to fall for the second male lead.

This feeling is horrible because you shouldn't be rooting for the second lead in this love triangle but you are, it's like an identity crisis.
"So I was watching my Kdrama last night and started getting second lead syndrome"
"You what?!"
"No cap. It's horrible but I can't stop."

second hole 

in anal sex, this is the deeper part of the rectum where the colon begins. There is a muscle there that like the rectum has to 'open up' and for men who are endowed enough to reach it, feels like hitting 'the second hole' inside the first one.

A term often used by gay men
Let me open up that second hole with this nine.

That nigga with the big dick got all up in the second hole!
second hole by BlkChicago79 April 21, 2006

Second Hand Retardation 

When your IQ lowers due to an encounter with an individual who is low in intelligence, also can be referred to as "second hand autism".
"God I think I got second hand retardation after talking to that dumbass!"

"Dude I saw you talking to Rawny, be careful! You may get secind hand retardation after conversing with that vegetable!"

"I think I fell victim to second hand retardation I can feel my brain cells killing themselves!"

second alibi 

Second Alibi is a short-lived pop duo best known for their hit song "Red." The won an Ohio Music Award in 2015 and toured with Aaron Carter 2017.
Second Alibi is a 2010's pop group.
second alibi by KellRobs92 February 27, 2019

Second heartbeat 

A thumping or throbbing expressed by the female genitalia during periods of sexual arousal, response, frustration, or climax. Described by many as being similar to a heartbeat
Just found out guys can feel your second heartbeat and I used to sit on my ex’s lap all the time. Time to drink the pain away
Second heartbeat by Sen. Kammy February 13, 2020