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Nice Guy Syndrome 

When a poor nice guy can't get a girl to like him just because she
- already has a boyfriend

- thinks he is completely unattractive
- doesn't like his personality
or because he
- is a total neckbeard
- doesn't understand social cues
- is probably a brony, furry, etc.
- calls himself a "pickup artist"
- wears a fedora everywhere he goes
A neckbeard says, "I can't believe Stephanie won't dump her boyfriend and be my girlfriend. Girls always go for the douchebags when they could have a guy like me who will love them and respect them!"
His non-neckbeard friend replies, "Dude- you've totally got Nice Guy Syndrome! Go jack off to My Little Pony or some shit."
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Nice guy Syndrome 

A disease flooding younger adults who compel them to be complete and utter assholes to women because the aren’t interested and don’t know how to let the guy down gently
Person 1. Man, I heard that Chad has a case of nice guy syndrome

Person 2: well, that’s no surprise

cool guy syndrome

when your coolness is so high you have to take adderall to keep it at bay
"why is so damn hard for you to pay attention"
"✨cool guy syndrome✨"
cool guy syndrome by maxmaxwoo April 4, 2022

Family Guy syndrome 

Someone who has watched so much Family Guy that they continually make references to cutaway gags or moments from Family Guy in relation to real life scenarios
Friend: so I've been growing out my beard and...

Family Man Addict: HA! That reminds me of the episode where Peter's beard becomes a bird nest

Friend: man you gotta lay off the show, you're developing family guy syndrome

Family Man Addict: Just like the episode where peter thinks he's inside a TV show

white guy syndrome 

(W.G.S) The consistent inability of white people to do/understand aspects of African American culture. This includes not understanding rap and hip-hop lyrics, dancing badly to music, and failing at playing funk.
Billy had white guy syndrome (W.G.S) so no one would dance with him at the club.
white guy syndrome by kenarchist November 15, 2009

Nice Guy Syndrome 

The disease which makes it virtually impossible for a heterosexual man to ever have a date, sexual entercourse or a relationship with a heterosexual woman.
Mark hasn't had a girlfriend in decades because he has Nice Guy Syndrome
Nice Guy Syndrome by Wildaubro September 12, 2015

short guy syndrome 

a short male who buys an oversized truck, works out to become as buff as possible, buys a very masculine large dog such as a boxer or pitbul, in order to make up for how tiny his dick is and how short he is.
wow, such a nice monster truck... the man who owns it must suffer from short guy syndrome. I feel so bad for the poor little man.):
short guy syndrome by hiddenstar December 24, 2014