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screw you billy 

What Jacksepticeye says during happy wheel gameplays, usually while playing the character known as "jb"
Jack: I died again!?! SCREW YOU BILLY!!

screw you guys im king lesbian 

when your local kwel jewish friend is in love with his lesbian teacher but yet doesnt know what lesbain means so---
Kyle "screw you guys im KING lesbian"

Screw you and your box

Meaning screw you and your household but you are implying thaat they are poor and they live in a cardboard box thus making it more insulting.
Screw you and your box then!

Screw you guys, I'm going home 

The catchphrase that is said by a fatass who wants to go home/is tired of his friends.
Cartman: "Screw you guys, I'm going home."

screw you we're from Texas 

a simple phrase that declares the superiority of people from Texas
New Yorker: I don't like BBQ and I don't understand Sweet Tea

Texan: Screw You we're from Texas

screw you and the horse you rode in on 

a phrase with origins in the late 20th century used to tell someone that they are being assanine, incosiderate, rude, or prickish.
You: Hey amigo would you keep that damn music down? I work third you know.

Latino Neighbor: Ese its Cinco De Mayo, the celebration for the freedom of my country!

You: Why dont you celebrate later buddy oh yeah and Screw you and the horse you rode in on!