PLS 

A very pleasant name for a horrible disease (primary lateral sclerosis)

I got PLS, now I can’t walk

PLS by Grixxlee September 11, 2023

Pls 

Shorthand for please, but nowadays since texting shorthand isn't really used, it has actually become something of a separate entity. It has made it into verbal speech, such as "lol", and is pronounced "plz" or "pluz". In this context, in in and of itself can be used to mean:

"oh please" used to call out one's bullshit.
or
"please no" a subdued beg for mercy, usually from an online roasting.

"I had sex with this really hot girl!"
"Pls"

"Everyone has to learn it by tomorrow. Especially Jason"
Jason:"Pls"

Pls by Dr. Futality August 16, 2017

pls 

Pls is a slang word used when something is ultra funny, it is often used with lmao.

Pls lmao

pls by cindua May 23, 2021

pls 

Short for "please", used in email by lazy asshats who put the minimum possible effort into being polite. Usually used in messges demanding something that's trivial for them but a PITA for you.

To all staff: Pls make sure your T.P.S. reports have the proper covers.

pls by fax4voice3 April 6, 2005

pls 

pls = please

more specifically, it's used as an appeal.

Example 1: You think that ghost story is true? pls.

Example 2: Donald Trump is a good president? oh pls.

pls by @pgoughy June 21, 2020

PLS 

Parking Lot Syndrome. When a group of friends stand around in the parking lot talking and chatting after dinner, a movie, or an event. This usually occurs when deciding on what to do next and can last a few minutes. However, it's only considered PLS if it lasts a considerable amount of time.

"Let's get rid of this PLS and decide where to go already! We've been out here in this parking lot for an hour and I wanna do something!"

PLS by makalive45 February 14, 2007

PLS 

Post Lunch Sleepiness: The greatest and most dangerous disorder in America today. It affects millions of American workers and or students each and every weekday of the year. The symptoms include lethargy, a strong urge to sleep no matter where you are at the moment, and an inability to focus on anything no matter how interesting it may be.

Monty: Man, I just finished lunch like an hour ago, and now I got a severe case of PLS.
Ryan: PLS?
Monty: Yeah, post lunch sleepiness
Ryan: Oh yeah, I had that real bad on Tuesday, and fell asleep under a pile of phone books in the supply room. When I woke up it was 6 at nite, and everyone was gone.
Monty: Yeah, PLS sucks.

PLS by Montay March 26, 2008