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Goofball 

When you mix heroin and crystal meth together in a shot. West coast slang.
That goofball sent me to the moon for hours.
Goofball by dabqueen710 June 4, 2016

Goofball 

A total idiot, someone who lacks any intelligence at all.
my little brother is such a goofball
Goofball by knobgoblin August 28, 2009

Goofball 

Formerly and through the late 1980s anf 1990s, slang for barbiturates. Later expanded in common vernacular to include benzodiazepines (such as Xanax and Valium).

Commonly used today to describe the recreational combination and use of heroin and methamphetamine via IV injection.
When cooking up a hit of dope, "I got a couple points of shards, too; you wanna slam a goofball?"
Goofball by Fuckingspiders October 3, 2016

Goofball 

Someone who is silly or stupid. Also looks silly or stupid.

Opposite of a chill bro.

People generally laugh at them than with them.
A: Do you know Declan?
B: Nah, I don't.
A: You know, the massive goofball?
B: Oh, yep! He's the king of goofballs.
Goofball by Double Denim Ranga August 2, 2010

goofball 

west coast slang for crystal meth and heroin in the same intravenous shot. it is not to be confused with speedball (cocaine and heroin)
jay: I got clear and black you wanna goofball?
jesse: im on my way let’s get goofy.
goofball by amphboy January 18, 2019

Goofball 

Your ride and die buddy. Someone that's aloof and silly asl and has something you don't (if you're a girl). Goof + ball = Goofball
u/creativename62 : Soo, how'd you come up with Goofball

his future gf: I wanted it to be wholesome and funny. So, 'goof' for your personality and weird ways and 'ball' for something I don't have. :D

him: Bruh
Goofball by YeshQueen June 4, 2021