To be “Lofty” one must be under the influence of prescription drugs. Usually it is Norco, Percocets, or Oxy initiated. The feeling is when the drugs finally hit you and you feel like you are on a cloud. A complete numbness throughout your body penetrates you. The term “loft” refers to a higher place, which is where “Lofty” comes in. You are in a loft within yourself, an elevated sensation not usually experienced.