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literally meaning bat feces, it can be substituted for shit as a much cooler alternative
Holy guano! This place smells like guano!
Guano by Tehpola June 27, 2004
To go completely bat shit; driven to the brink of insanity.
"Man, if I have to hear Babci's story about how she beat up that guy in the bar in '43 and they rolled out into the street in front of the bus I'm gonna go guano"
guano by shannonkg June 13, 2007
a substance composed chiefly of the excrement of seafowl and used as a fertilizer; aka bat sh!t
guano by snoopid September 13, 2004
Guano mines as a source of nitrate, producing 84% of the world's supply of fertilizer, a $1.4 billion industry.
Guano. Hello. Does "poo" ring a bell?
guano by CartoonChess July 22, 2004
1. Avian fecal matter. In the 18th and 19th centuries, the North American Guano Company would send ships to south-Pacific islands to harvest the guan, which was used as fertilizer. (seriously!)

2. Bad news or something unpleasant and unflattering.
1. We used to have to import our <i>guano</i> from Mocronesia, but today we produce so much bullshit in Washington, that we no longer need the bird shit!

2. Wendy really dumped a load of <i>guano</i> on me when she said we were breaking up!
guano by Malcolm X-crement November 16, 2003
I had to clean some guano of my car.
guano by mic March 16, 2003