To go completely bat shit; driven to the brink of insanity.
"Man, if I have to hear Babci's story about how she beat up that guy in the bar in '43 and they rolled out into the street in front of the bus I'm gonna go guano"
by shannonkg May 25, 2007
a substance composed chiefly of the excrement of seafowl and used as a fertilizer; aka bat sh!t
by snoopid September 14, 2004
Guano mines as a source of nitrate, producing 84% of the world's supply of fertilizer, a $1.4 billion industry.
Guano. Hello. Does "poo" ring a bell?
by CartoonChess July 22, 2004
1. Avian fecal matter. In the 18th and 19th centuries, the North American Guano Company would send ships to south-Pacific islands to harvest the guan, which was used as fertilizer. (seriously!)

2. Bad news or something unpleasant and unflattering.
1. We used to have to import our <i>guano</i> from Mocronesia, but today we produce so much bullshit in Washington, that we no longer need the bird shit!

2. Wendy really dumped a load of <i>guano</i> on me when she said we were breaking up!
by Malcolm X-crement November 16, 2003
I had to clean some guano of my car.
by mic March 17, 2003
eskimo word for pegnuin droppings
It is guano.
by gwano October 28, 2003