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No mames 

“compa/homie i think I got my girl pregnant man

“No Mamesguey”
No mames by Misfit11 January 11, 2018

no mames 

It's a mexican slang that has 3 meanings:

1. it's a vulgar or informal way to say "you're kidding"

2. it's a vulgar way to say "stop messing around"

3. sometimes can be used like saying "no way"

4. or when you're scared or desperate and you suddenly say "no mames" just because nervous or something like that and when you say that word is like saying "damn".
guy1: Karina said that you're going around with Jose

girl1: no mames !!!
no mames by Brendiux Le Doux December 5, 2004

no mames guey 

A Spanish slang phrase commonly used by Mexicans. Geuy means a jerk (other translations for guey are dude, bro, punk, and more), but young Mexican people use it to adress their friends in a teasing manner. The whole phrase "no mames guey" translates as "You must be kidding, man!" but most people use it refering to its other definitions, such as "Don't fuck with me!" or "Don't give me shit!"
1. Non agressive example ("you must be kidding"):

"Yea, so I just bought a new TV which is flatscreen and HD!"

"No mames guey! Thats awsome."

2. Agessive example ("don't fuck with me"):

"Hey, will you ask your mom how much I owe her for last night?"

"No mames guey!"
no mames guey by maxicanjew June 28, 2009

no mames 

comes from the word mamar, meaning "suck" in spanish.
Mexican slang for : "you're kidding"
Mexican slang for : "Stop messing around"
guy 1: Yesterday I saw Madonna in my back yard
guy 2: No mames!

guy 1: Maybe you can dress in drag...
guy 2: No mames...
no mames by stardelice August 8, 2004

No mames 

Is a way to say 'don't joke about that' but in a way less serious, like 'no wayy men'
Is only said by close friends.
Is aslo said because a tragic happend unexpectedly.
Carmen descubrió que su novio le fue infiel
- qué?! No mames
No mames by Thaid March 8, 2018

no mames 

mexican slang for fuck off. polo polo says it a lot if you want the correct pronunciation.
girl: i love you
dude: ya no mames cabrona
no mames by chingona April 1, 2005