Yeast Cream Share definition Flag Insult of 2008. Modern answer to the overused douchebag. Also commonly spelled yeast creme. "Dude, why are you being such a Yeast Cream?" "You're as nasty as Yeast Cream on toast." Yeast Cream by Kiddyphenil06 October 12, 2008 0 0 Get merch Get the Yeast Cream mug. Buy Now — $32.95 See more merch