One would say it while losing an argument or after being insulted; usually used by french speaking canadians.

ESTI FUCK YOU
by oqk January 12, 2011
Get the STFU mug.
Stfu is usually short hand for SHUT THE FUCK UP!! But in other , more uncommon cases it means:

SAVING TURKEYS FROM UNICORNS - D-CHIP! ^ ___ ^

Or

Seven Thursdays From sUnday
Anon: What should we call our band?
Mudkip: Kicking Wood w/ Not Politically Correct Folk Singers.
Anon: OH Lol'd. No we gotta make it epic!
Mudkip: STFU?
Anon: lol wut?
Mudkip: Saving Turkeys From Unicorns.
Seaking: FUCK YEAH!!
by Wings of Lead February 2, 2008
Get the STFU mug.
"SHUT THE FUCK UP", commonly used to blatantly intimate that someone is being annoying.
by Kevin says STFU February 13, 2006
Get the STFU mug.
STFU= Shut The Fuck Up

When you want someone to keep quiet but can't say it aloud because you are out in public or your parents or your boss is there.
My girlfriend was annoying everybody with her constant meaningless chatter. Finally, I turned to her and said, "Jean, STFU."

I was walking down the street when the dogs behind the fence started to bark. I yelled, "STFU, STFU."
by Rust John Tommy Rude April 24, 2007
Get the STFU mug.
STFU - Swim to france, ugly.

Often used when you want an ugly person to remove themselves from your view, subject to failure if used in france.
guy 1: STFU n00b
guy 2: but I can't swim.
by Kinky pinky April 4, 2005
Get the STFU mug.
a trademark submission move of WWE superstar and current WWE champion, John Cena
Bob: "Did you see Cena make Khali tap out to the STFU at Judgement Day 2007?"
Alex: "Yeah, that was totally amazing!!!!! He's the first to ever beat Khali!"
Get the STFU mug.