sista fran 

a person that is very close to you and you love like a sister. you tell them everything and are best friends. you are almost always with each other. sista frans are BEYOND just friends

Shea: is that girl Katie your friend?
Carly: She's not only my friend, she's my sista fran

or
Katie: hey sista fran, what's up?
Carly: nothing much, wanna hang out. go shopping or something?

sista fran by runnergirl365 February 24, 2011

sistafran 

When you get excited you can refer to the person you're talking to as Sistafran.

"I am a communist."
"OMG SISTAFRAN! NO WAY, ME TOO!"

sistafran by Mike I May 6, 2005