A person who's got large muscles, but isn't cut up. Thus, the person ends up lookin swollen all over. Not necessarily fat.

Can be caused by the consumption of too many protein shakes without proper aerobic exercise.
Eric: Vince Vaughn? That puffy motherfucker?
Johnny Drama: No bro, he didn't look puffy at all... He was lookin' real good.
by mikey roulette May 23, 2008
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A nickname for a girl who has pleasantly large breasts. Often describes a woman who is vain about her shapely mammary glands.
Vicky: They call me Puffy!
Doug: Why?
Vicky: I don't KNOW!! (thrusts breasts violently into Doug's face)
by Implying713 July 9, 2011
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Jonathan's hair when it has yet to be brushed in the morning, or, whenever he shakes his head very very fast.

Christine: "WHOA! Look, Jonathan has puffy hair!"
Rebecca: "I like it like that! Puffy hair is sexy!"
by The loud one. March 8, 2009
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Sean John Combs (born November 4, 1969), also known by his stage name "Diddy." Also formerly known as Puff Daddy and later, P. Diddy. He dropped the "P" from P. Diddy because it "got between him and his fans." Mr. Combs is a hip-hop mogul, producer, actor, and marathon runner.
Guy 1 - "Yo dude how many miles are in a marathon?"

Guy 2 -"I don't know man, let me call Puffy right quick and find out."
by Black Bauer June 14, 2010
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nate got a puffy when he met the chick he was talking to online
by baby girl August 12, 2003
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can be used as noun, adjective, profanity or nickname.
noun=an extremely cool person.
adjective=amazing
profanity=synomyn of f***
nickname=a nickname for someone that demonstrates puff-like qualities (i.e: coolness, awesomeness, enthusiam)
"Woah! Look at that Puffy! She's so cool!"
"Holy crap! Thats puffin' awesome!"
"PUFF YOU"
"Oh jen, you're so cool, i think i'll call you Puffy from now on...cause you're just that cool."
by Puffster March 10, 2009
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A moderate to substantially overweight female's vagina
I'd rather die than see Roseanne's puffy
by jjssrr May 1, 2010
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