Procaine is a local anesthetic drug of the amino ester group, which acts through multiple targets.
Target: OthersProcaine is a local anesthetic of the ester
type that has a slow onset and a
short duration of action.Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a
KD of 1.7 microM 1. Procaine is a
DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine
DNA content as determined by
high-performance capillary electrophoresis or total
DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest 2. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale 3.
Procaine Technical measures: Handle in a well-ventilated place. Wear suitable protective equipment. Prevent
dust from spreading. Wash hands thoroughly after handling
and face.
Precautions: Use
local exhaust if
dust or aerosols are generated.
Handling Precautions: Avoid contact with
skin, eyes and clothing.
storage
Storage Conditions: Keep container tightly closed. Store in a cool, dark place.
Store away from incompatible materials such as oxidizing agents.
Packaging materials: according to the law.
