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A synonym for something being 'cool' or 'alright'. It is frequently used in southern England to show other people that you are calm and that you have understood what they said. Most commonly used in practice with the word 'okay' or 'alright' in front of it.
1: Hey man, I'm off to Chicago
2: Okay, polio, take care

1: Drop the gun!

2: Alright, polio, relax!
Polio by The Bear of England March 30, 2011
Very strong marijuana or the state of being highly intoxicated from marijuana.
Dude, let's fire up the polio.

(Observing someone who is very obviously stoned out of his mind) He's got the polio.

I'm totally polio'd now man. I'm gonna go crash.
polio by RickySunnyvale420 February 20, 2011
Someone completely useless to all human society.
A sped, spaz or retard.
"Lets get together after school and watch the polios attempt to swim! And fail, of course."
or
"John told us he was eating lunch, but when we looked he was eating his shirt. What a polio, lets discontinue our friendship with him."
polio by fitz much? February 26, 2008
adj; normally used in place of words that are supposed to mean "cool," such as "mean," or "bad"; the "worst" form of "cool" you can be. I mean, what's worse than polio?
"DUDE, that car is MEAN."

"No way, that car is so POLIO."
polio by flamingos January 30, 2009
Bitches can't walk!
My wife has polio. Oh, so that bitch can't walk?
Polio by Jic Bassey January 2, 2021

Polio Day 

1. The day spent in bed nursing a hangover

2. Following a night of heavy drinking/debauchery you might spend the next day sitting in bed watching day-time TV or re-runs from the comfort of your bedroom

3. Being so hungover or ill that you are unable to physically move your legs and leave the bed
Examples:

1. The day after his 21st Birthday, Chris had a Polio Day and spent his time watching all of Dexter Season 2.

2. The Dickinson College student was so sick after a night of drinking that the entire next day was a Polio Day and he did not move his legs once.
Polio Day by CC89 July 11, 2011