on one

Just generally trippin', tweakin', weird, actin' a fool, blackin' out, goin' off. Not necessarily due to drugs, though that's the obvious reference.

Homie was on one, just buggin' like I shot his mom or something.

by Kuahmel January 23, 2009

on one

to be under the influence of methamphetamines

i heard joe's been on one for the past three days

by Leya Fish January 20, 2003

on one

To be under the influence of methamphetamines AKA ice,meth,speed,dope,etc.

Tuttie's on one man, he been smokin' ice all week!

by rooster760 March 01, 2005

on one

Feeling way too good.

Just broke up with my girl and this alone time has me feelin' on one right now.

by Fresh Livin' May 05, 2015

on one

to be high, faded, to have just smoked weed.

My man James was on one at the party.

by metalgearray February 20, 2005

on one

horny randy upforit madforit gaggingforit right-on-it etcetc

see above

by jeff May 04, 2003

one on one

1. A game where the only opponents are two people playing against each other.
2. Also know as speedballing; a mixture of cocaine and herion, most often injected.

1. Jack says to Tommy, "Let's play a game of one on one"
2. After getting out of lock-up, I said to myself, "I'm 'bout ready to head downtown and gets me a one on one!!"

by dieselgirl August 07, 2003