number three combo Share definition Flag when you are peeing out of your urethra, and peeing out of your asshole (really bad diarrhea) "what was going on in there?" Damn, I drank too much yesterday, that was the "number three combo". number three combo by poo talk January 13, 2009 0 0 Get merch Get the number three combo mug. Buy Now — $32.95 See more merch