A common nickname for the STD known as gonorrhea. People give this name to compare their spotty sack to Mr Tumble's spotty bag.
MrTumble'sspottybag is his bag which is a recurring weapon in the anime.
Person A: Do you have Mr Tumble's spotty bag?
Person B: Ew no gross... I use protection!
Person C: Lift your hand just like so.
Person A + B: Do you have Mr Tumble's spotty bag?
When some resigns or retires from a job, they are on "eternity leave". This can also refer to someone who has passed away, especially someone who worked somewhere for a long time, retired/resigned, then passed away later.
Oh I'm sorry, you didn't know that Kelly is on eternity leave? She resigned and moved to Hawaii!
With regrets I would like to inform you that my boss is officially on eternity leave. I will never see or hear them again. Ever.