monoboobulosis Share definition Flag A disease in which a man or woman is born with one boob. -Often found in old, fat, vulgar woman. Sarah Wheeler and your neighbor have one tit, therefore they have monoboobulosis. monoboobulosis by Lindan October 4, 2006 0 0 Get merch Get the monoboobulosis mug. Buy Now — $32.95 See more merch