lay one out

To drop a deuce, dump a load, or otherwise take a crap.

After finishing all that Mexican, I had to lay one out.

by Amsterdizzle July 27, 2006

Lay one out

Lay-one-out (southern phrase). When one chops out a line of cocaine to be shared or to take to the dome by one’s self.

Myrtle beach, myrtle beach. I’m gonna lay one out when I get there.

by Jcoop336 June 28, 2023