A play on the word laughing gas, also known as nitrous oxide or N2O for the nerds
example in everyday conversation
Patrick: i just killed someone and fucked them in a Tranux
Paolo: a WHAT!?
Patrick: Look it up the definition, it might give you a laughing gAss
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.