The drowsy sleepy feeling you get after eating a large meal. Usual meals like big Sunday dinners, Thanksgiving and Christmas meals.
Man that itis done got me. I'm fixin' to take a nap.
by Malinen23 December 12, 2005
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That drowsy feelin u get after a big ass meal. U usually dont want to do anything or have lost the energy to do so. Recently popularized by black people
If u go over to yo grama's house and she cooks up a good meal like she always does u would get the itis from dat.
by Andre Benjamin December 5, 2007
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the feeling of wanting to do nothing but sit on your porch and smoke a blunt and drink a 40oz
by the officer May 9, 2006
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That sinking feeling in your bowels after an especially greasy meal. Another name for mud butt. Most often heard after meals to Taco Bell.
Damn, I got the itis, where's the restroom.
by Ryan Eshelman January 23, 2006
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To counter the sarcastic use of 'isit?'. Can also be used sarcastically to show lack of interest/disapproval in something one is saying.
Dec: FarCry2 isn't that bad

Tom: Isit (disapproval sarcasm)

Dec: Itis.


Tom: Is that the one who called you a legend?

Dec: Itis
by TrueQuiche November 2, 2009
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When you eat a large amount of food and soon after feel really tired
Man that half apps gave me the itis
by niggrumps September 30, 2014
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The general feeling of lethargy and well-being experienced after eating a satisfying meal. This phenomena is particularly triggered by foods high in carbohydrates and meats containing the amino acid tryptophan.
I got the itis so bad after the Thanksgiving meal I just chilled on the couch and watched some movies.
by Dorjan Scott February 16, 2004
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