The drowsy sleepy feeling you get after eating a large meal. Usual meals like big Sunday dinners, Thanksgiving and Christmas meals.
Man that itis done got me. I'm fixin' to take a nap.
by Malinen23 December 12, 2005
That drowsy feelin u get after a big ass meal. U usually dont want to do anything or have lost the energy to do so. Recently popularized by black people
If u go over to yo grama's house and she cooks up a good meal like she always does u would get the itis from dat.
by Andre Benjamin December 5, 2007
the feeling of wanting to do nothing but sit on your porch and smoke a blunt and drink a 40oz
by the officer May 9, 2006
That sinking feeling in your bowels after an especially greasy meal. Another name for mud butt. Most often heard after meals to Taco Bell.
Damn, I got the itis, where's the restroom.
by Ryan Eshelman January 23, 2006
To counter the sarcastic use of 'isit?'. Can also be used sarcastically to show lack of interest/disapproval in something one is saying.
Dec: FarCry2 isn't that bad

Tom: Isit (disapproval sarcasm)

Dec: Itis.

OR

Tom: Is that the one who called you a legend?

Dec: Itis
by TrueQuiche November 2, 2009
When you eat a large amount of food and soon after feel really tired
Man that half apps gave me the itis
by niggrumps September 30, 2014
The general feeling of lethargy and well-being experienced after eating a satisfying meal. This phenomena is particularly triggered by foods high in carbohydrates and meats containing the amino acid tryptophan.
I got the itis so bad after the Thanksgiving meal I just chilled on the couch and watched some movies.
by Dorjan Scott February 16, 2004