The phrase refers to content focused on interactions with unrealistic size differences, typically in an SFW fashion. As the name implies, these interactions usually happen with a giant character, and a tiny character, though ordinary human-sized characters are generally accepted in the mix.
Boys who enjoy yaoi (a genre in Japan that contains sexual and/or romantic relations between two men); literally translates to "rotten boy"; corresponding female : fujoshi
May I have an order of regular degular buttermilk pancakes? Without all the added jazz? Hold the blueberry smiley face, strawberry glaze, chocolate chips and whipped cream.