Pretty much means anything you want it to. Your teacher randomly gives you a pop quiz? You got memed on. You accidentally go left instead of right? Memed on. Originated solely because I started to say “get dabbed on” unironically, so I needed to think of something worse than that.
Ruler of Lake Titicaca. Rumored to have a bunghole that gets very angry if it does not receive toilet paper. Cornholio the Great is often seen walking around with his shirt over his head and his hands in the air, chanting songs about his power, and his bunghole.
"I am Cornholio! You do not want to face the wrath of my bunghole, for I need TP!"
Butthead: Shut up, Beavis! (uh huh huh huh)
Beavis: Um, okay. (heh heh heh heh).