Refers to the person you are talking to or talking about. It takes the place of words like "fool,""nigga,"and "dog" when used on the streets by youth. In 2007 it is mostly used by gang members or by people refering to Mexican American gang members, but not exclusively. The word was used long before the Mexican Mafia, or surenos, existed. Pachucos, Mexican American zoot suiters of the 1940s, used the word ese in Los Angeles, Tucons, El Paso, San Jose, Albuquerque, Gilroy to name a few documented locations. It is true that todays' Mexican American gang members from northern California, aka nortenos, refrain from saying the word ese. This is because "ese" is how you pronounce the letter "S" in Spanish and they take that as referring to "S" for surenos, Mexican American gang members belonging to the 13, the Mexican Mafia that originated in southern california but is now in northern california and other U.S. states.

Bascially the same thing as "nigga" but instead it's structured for mexicans. Avetards and some intellectuals like to refer to an ese and an essay as the same thing because it's pretty fun.