The epitome of a friend. Somebody you kick it with. A person who always has your back. You can't go through life without a homeboy. It's hard to have more than one, because they're one in a million.
by Poopdeck222 March 28, 2007
Contrary to popular belief, homeboy along with homie were both created by Chicano aka Mexican American Pachucos from the word "Hombre" which is spanish for "man". It all derived from the slang they used known as "Calo".
Chuco #1: What's happenin homie??

Chuco #2: Just kickin it with my homeboy.
by rob-g April 14, 2007
In the California Prison system a "Homeboy" is someone from the same race and county you are from whom you are on good terms. Your "Home" town etc
Have you met Dan yet, he's also from Sacramento, he's one of your Homeboys!
by Dan-G-erous July 21, 2011
home boy to a girl is a great friend who has her back and is real too the end
johnni noi from the big d is ka8e babybez homeboy.
by opitsindrumn0120012small September 4, 2015
The term "homeboy" derrives from "homie", and each of those terms have been shortened down overtime as "homes", or sometimes spelled "holmes". The term was started by Mexican-Americans living in the barrios of Los Angeles, most commonly said in East Los Angeles. The term refers to friends/companions living in the same neigborhood as eachother. Which is why "HOME" is started before boy, thus creating "homeboy".
Person 1: Aye whats happening homeboy?
Person 2: nothing just chilling, you?
Person 1: about to go to Rob's house...
Person 2: who that? is he a homeboy?
Person 1: Nah... just some foo i kick it with from Grape Street.
by Eddie.P March 24, 2007