don't get your knickers in a twist Share definition Flag when one gets upset or crazy over something most people think is unimportant Sally don't get your knickers in a twist over that split milk on the floor, silly Sally! don't get your knickers in a twist by MoreBudlight November 10, 2013 0 0 Get merch Get the don't get your knickers in a twist mug. Buy Now — $32.95 See more merch