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to give up or to quit. to stop doing.
yo, that bitch need to come off that attitude for real.

you need to come off that dumb shit man and get with it.
by A6 from DeepBlue August 11, 2008
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to give or to release
She need to come off some shares of her startup company to her advisors.
by Rigo April 28, 2006
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A very Cockney (East-London Slang) phrase, used to express rejection or disbelief. It can also used in a friendly way.
by NoStringsOnJay December 15, 2015
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disagreeing with something someone has just said. quite litterally "no way" or "get out of town", "get the fuck out" "get out" "take off"... you get the idea.
"oh my god i'm like sooooooooo fat."
"oh, come off it."
by missanthropy February 16, 2006
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The action of a female who proceeds to have sexual intercourse with another. If a female is considered a slut she will naturally come off it much easier than someone who sucks and sits on it.
"Jennifer is really hot, but does she come off it?"

"Hey bitch, you comin' off that pussy or what?"
by A-Slam September 5, 2007
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To tell someone that they are not thinking straight and they need to get real!
(Frank)
Come off the grass, for heavens sake, there is no point debating the issue, it is illegal and therefore it is not the right thing to do.
by VICKI KARMA November 11, 2006
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