This expression is similar to "what goes around, comes around" and basically means that the consequences of one's evil actions catch up in a negative
way. The idea that a wrongful curse comes back to the one who curses as a "bird returns to its nest" dates back to the days of antiquity. However, it wasn't until the 19th Century that Robert Southey wrote that "curses are like a young
chicken: they always come
home to roost." Since then, the idea of evil men creating returns to their own
door has been encapsulated in this expression.
Dude, you keep dealing drugs and you're going to get caught. When the chickens come
home to roost, they will take your
car, your house, and all your
money!