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An obscure illness, disease or condition affecting a comparatively small number of people, but with symptoms somewhat similar to one or more different and more common illnesses.

It is named because these diseases/conditions are sometimes misdiagnosed by well meaning (but often inexperienced) doctors when something far more common is actually the cause. Medical students are told "remember, if you hear hoof beats, think horses, not zebras".
Doctor 1 - "I think this patient may have Castleman's disease"
Doctor 2 - "Castleman's disease is a zebra, there are far more likely causes of his fever and weight loss."
by PiemasterUK December 08, 2010
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Sep 6 Word of the Day
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Damn that was a steezy ass kickflip son!
by niggaliciouszor April 29, 2007
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TWENTY-FIVE sizes larger than a A bra.
Fat beatch had milkers so large that she needed a zebra to contain them.
by Cosmicstargoat April 26, 2004
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4
(n) common slang term for referees or field officials in certain sports (particularly in American football) due to the white and black striped uniforms
That zebra should be hunted down for that assinine 'pass interference' call.
by methodmadness March 17, 2004
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Any of several swift, wild, horselike African mammals of the genus Equus, having distinctive overall markings of alternating white and black or brown stripes.
Is that Zebra black with white stipes or white with black stripes?
by Caitlinn July 06, 2005
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