An obscure illness, disease or condition affecting a comparatively small number of people, but with symptoms somewhat similar to one or more different and more common illnesses.

It is named because these diseases/conditions are sometimes misdiagnosed by well meaning (but often inexperienced) doctors when something far more common is actually the cause. Medical students are told "remember, if you hear hoof beats, think horses, not zebras".
Doctor 1 - "I think this patient may have Castleman's disease"
Doctor 2 - "Castleman's disease is a zebra, there are far more likely causes of his fever and weight loss."
by PiemasterUK December 08, 2010
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When a chick was fat, she slims down
Leaving Stretch marks... reminding of Zebras stripes
That Girl is a Zebra...
by Kriix April 16, 2009
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Zebra is a woman who is free spirited and can not be tamed. They can be the most loving that you will ever meet but if you attemt to put a saddle on them they will run away
So im dating this girl....I really like her but im taking it slow because shes a zebra
by BIGGDAD September 13, 2009
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se-be-ra
It's an äänimäl, Pouliien. It has black and white strrripes.
"We gonna watch a film called "Zebra Head"!"
by Truthingerr September 18, 2017
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When you are having sex doggie-style with a black girl, and you cum on her back in stripes, making her look like a zebra.
Hey Steve guess what!" "What?" "I just zebra'd on Rhianna.
by mrfairyuniverse July 24, 2011
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