Wassup Holmes! 

The greeting taught when you take the first course of AP Mexican .
In Spanish 1, you're taught "hola" or "buenos dias."
In French 1, you're taught "Bonjour."
In Chinese 1, you're taught "Ni Hao."
In Japanese 1, you're taught "Konicheewa."
In Latin 1, you're taught "Lorem."
In Mexican 1, you're taught "Orale!"
After experience, in the rigorous course of AP Mexican, you're taught "Wassup Holmes."

Professora Maria: Pablo, how doo you saye the word "Hello" in dees classe's langwage?

Pablo: Wassup Holmes!

A month later...
Pablo: Mommy, Papi, look what I got in AP Mexican!

Mommy and Papi: Oh, Pablo, we're so proud of that A minus!

Wassup Holmes! by TheLegendwhosurvivedtheHood November 20, 2011

Yo! Whassup homes? 

A greeting that a person (usually but not always a black man) might say to a good friend of his when they approach one another.

{Edward}: Craig! Yo! Whassup homes?
{Craig} Hey there Edward! Just on my way to work. Wanna go grab a quick 40?

Yo! Whassup homes? by Telephony March 31, 2021