Twox Share definition Flag A combination of a woman's twat & a woman's 'box'. A term of endearment, if u will, (similar to referring to someone as a cunt) She's being bitchier than usual today... Yeah! She being a real TWOX! Twox by Angelo H. June 25, 2008 0 0 Get merch Get the Twox mug. Buy Now — $32.95 See more merch