Much the same as "living shit", "the bejesus", or "the devil"; for example, when you're beating the living shit out of something.
Andrew went on the rampage at work this morning when the copier spit toner all over him -- he literally beat the living tweedle out of the poor, defenseless, helpless copy machine!

Topher was so fond of his new R/C piloting skills; he flew the living tweedle out of his Cessna 182 R/C airplane at the park over the weekend.
by Telephony July 28, 2012
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Someone who goes into the jungle gets bitten by a tick or denge bug and catches a 5 day fever AKA jungle fever
I held on to the antibiotics incase I met sombody who would be such a tweedle duffer as to run though the jungle with no bug spray on.
by DemonWeapon April 15, 2017
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a person who gets bitten by a dangerous bug and gets the five day fever and doesn't treat it
Nami you are a real Tweedle Doofer
by RedbeanReindeer January 11, 2018
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Two male individuals who act as if they are joined together at their schwanzes.

Two guys that throw up on eachother's schwanzes.
Bobby and Eric act like they are Tweedle Dildo & Tweedle Dickhead at every sporting event they attend.

I'll tell you what dude, Siegfried and Roy are classic Tweedle Dildo & Tweedle Dickhead.
by Meekrab1 May 17, 2011
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a word that sounds bad, but really means nothing at all
last night I walked in on my roommate while he was tweedling the log
by turtlevagina September 5, 2010
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A pair of really stupid fatasses or jerkfaces. Also can be refered to as Tweedle dee and Tweedle dumb, Tweedle dum and Tweedle dumber or dumbass Tweedle extreemlyfkn dumb and Tweedle absolutley braindead.
by jc.owens March 26, 2008
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a simpleton, or any prick that thinks they know everything; a dumbass see chode, wad-pilot, dumbfuck
the tweedle fuck kept telling me, "potato chips have salt on them"
by cassius$ July 19, 2006
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