Cancer, Usually transferred through memes
Yesterday i caught The Big Oof.
by Thanos March 5, 2019
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Whenever something didn’t go your way it’s going going to be almost impossible to fully recover from.
Aw man, I heard that those two just broke up.. that’s a BIG OOF!
by Trashist April 10, 2018
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When the situation is so bad you need a louder Oof sound but can't replicate it.
Person one: Your forhead is so large you could put solar panels on them and power an entire city.
Bystander: that was a Big Oof
by Fetus deletus 445 August 28, 2018
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1. A Replacement for expressing pain, discomfort, or astonishment.
2. A way to announce that you have just witnessed ultimate savagery.
by Markymoist August 26, 2018
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An expression uttered when something is so cringeworthy, depressing, or hard to watch that that the expression OOF doesn't do it justice.
"Did you see the new Berry College logo?"
"Yeah...Big OOF."
by theRealColonelSanders December 24, 2018
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The disappointment so great it can only be discribed by the noise of hitting rock bottom
Belle still having Sasha on Snapchat was the Biggest of Big Oofs
by Lennontaylor January 31, 2019
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