To wipe out half of any population on any scale. Named after Thanos, a comic book villian in the Marvel Universe who wanted to wipe out half of all life to create balance
To make something look like Thanos by painting it purple and sometimes giving it a big chin
Customer: "Excuse me, where can I find thanosized shirts?"
Employee: "We have purple shirts over there" *points somewhere*
Customer: "Thank you, that does put a smile on my face"