1. A polite and well meaning colloquialism. This phrase gained popularity when famed rapper/pornographer/movie star Snoop Dogg started using it and other words containing the suffix "izzle" or "izzy."

2. To informally aquiesce or agree with someone whom you consider an affable peer.
My friend Tim was like, "Whassup Dog, are you going to the game tonight?" I responded "Fo' Shizzle my nizzle" in the pitch of a tenor.
by Barry February 12, 2004
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For sure, my nigga. Should only be used by a black person, to a black person - unless you want your ass kizzled. Variations acceptable for use by whitey include:

fo' shizzle my sizzle = For sure, my sister.
fo' shizzle my bizzle = For sure, my brother.
Yes sir, Suge sir. Right away sir. = Please Suge, don't kill me.
Whitey 1: Hey man, are you going to the club tonight?
Whitey 2: Fo' shizzle, my bizzle. Right after I watch the game on my televizzle.
Whitey 1: Sorry Suge sir, don't kill him.
by udc March 12, 2003
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Archaic phrase used by African American slaves since the 17th century. A corruption of 'For shine his hall, my knees ill' it was used as a greeting by slaves who had to polish the floors of colonial mansions. Later became an unrelated greeting.
'Missie, missie - yo massah done made me polish dat whole corridor, an it done made my knees hurt terrible - fo' shizzle ma nizzle, an no mistake!' from 'Gone With The Wind' by Margaret Mitchell.
by Anonymous June 26, 2003
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fo shizzle my nizzle, or fo hizzle my wizzle, tranlates to: for sure, my nigger OR for sure my white-nigger. its mostly used by snoop dogg, dr dre, and eminem.
jay-z: "fo shizzle my nizzle used to sribble down in v.a"
by niggerina_hannah August 19, 2006
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A slightly aborted version of a declined McDonald's slogan:
Hamburglar: "Come robble my knobble."
by WASTELY March 16, 2003
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